Crossword clues for parkin
Wiktionary
Etymology 1 alt. A traditional soft cake of Northern England, usually made with oatmeal and treacle. n. A traditional soft cake of Northern England, usually made with oatmeal and treacle. Etymology 2
n. (context biochemistry English) A particular protein, mutations in which are associated with Parkinson's disease.
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Housing Units (2000): 657
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Total area (2000): 2.554493 sq. miles (6.616106 sq. km)
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Location: 35.265392 N, 90.554880 W
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Headwords:
Parkin
Wikipedia
Parkin is a protein which in humans is encoded by the PARK2 gene. The precise function of this protein is unknown; however, the protein is a component of a multiprotein E3 ubiquitin ligase complex which in turn is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Mutations in this gene are known to cause a familial form of Parkinson's disease known as autosomal recessive juvenile Parkinson's disease (AR-JP). Moreover, Parkin is described to be necessary for mitophagy (autophagy of mitochondria).
However, how loss of function of the parkin protein leads to dopaminergic cell death in this disease is unclear. The prevailing hypothesis is that parkin helps degrade one or more proteins toxic to dopaminergic neurons. Putative substrates of parkin include synphilin-1, CDC-rel1, cyclin E, p38 tRNA synthase, Pael-R, synaptotagmin XI, sp22 and parkin itself (see also ubiquitin ligase). Additionally, Parkin contains a C-terminal motif that binds PDZ domains. Parkin has been shown to associate in a PDZ dependent manner with the PDZ domain containing proteins CASK and PICK1.
Parkin may refer to:
- Parkin, a brand of the drug trihexyphenidyl
- Parkin, a brand name of Profenamine
- Parkin (cake), a type of cake
- Parkin (ligase), an enzyme
- Parkin (surname), people with the surname Parkin
Parkin or Perkin is a gingerbread cake traditionally made with oatmeal and black treacle, which originated in northern England. Often associated with Yorkshire, particularly the Leeds area, it is very widespread and popular elsewhere, notably in Lancashire. Parkin is baked to a hard cake but with resting becomes moist and even sometimes sticky. In Hull and East Yorkshire, it has a drier, more biscuit-like texture than in other areas. Parkin is traditionally eaten on Guy Fawkes Night, 5 November, but is also enjoyed throughout the winter months. It is baked commercially throughout Yorkshire, but is mainly a domestic product in other areas.
Parkin is a surname, and may refer to
- Alex Danger Parkin (born 1982), English Born Epsom, Surrey Philanthropist International Super Spy
- Arthur Parkin (born 1952), New Zealand field hockey player
- Ben Parkin (1906–1969), British Labour politician, MP for Stroud (1945–1950) and Paddington North (1953-69)
- Bonnie D. Parkin (born 1940), American 14th general president of the Relief Society of The Church of Jesus Christ of Latter-day Saints
- Brian Parkin (born 1965), English footballer
- Cec Parkin (1886–1943), English cricketer
- David Parkin (born 1942), Australian Australian Rules football player and coach
- Derek Parkin (born 1948), English footballer
- Dante Parkin (1873–1936), South African cricketer
- Edmond T. Parkin, Canadian architect
- Frank Parkin (born 1931), British sociologist
- George Parkin (1903–1971), English footballer
- George Robert Parkin, (1846–1922), Canadian educator and author
- Gerard Parkin, American chemist and metallurgist
- Ian Parkin (1950–1995), British musician ( Be-Bop Deluxe)
- Jasmin Parkin (19??-), Canadian singer and keyboardist ( Mother Mother)
- Jennifer Parkin, Canadian musician (Ayria)
- Joe Parkin, American professional cyclists and author
- John Parkin, British television presenter
- John B. Parkin (1911–1975), Canadian architect
- John C. Parkin (1922–1988), Canadian architect
- Jon Parkin (born 1981), English footballer
- Jonty Parkin (1894–1995), English rugby league player
- Lance Parkin, British author
- Leonard Parkin (1929–1993), British television and news presenter
- Molly Parkin (born 1932), Welsh artist and journalist
- Owen Parkin (born 1972), English cricketer
- Philip Parkin (born 1971), Welsh golfer and commentator
- Ray Parkin (1910–2005), Australian writer, artist and historian
- Ray Parkin (1911–1971), English footballer
- Sam Parkin (born 1981), English footballer
- Sara Parkin, British Green Party politician and environmental campaigner
- Scott Parkin (born 1969), American environmental campaigner
- Sophie Parkin (born 1961), British author and actress
- Steve Parkin (born 1965), English footballer and manager
- Steve Parkin, Australian musician
- Stuart Parkin, British experimental physicist
- Terence Parkin (born 1980), South African Olympic swimmer
- Tim Parkin (born 1957), English footballer and manager
- Tommy Parkin (born 1956), English footballer
- Travis Parkin (born 1949), American radio DJ
- William Parkin (1801-1889), South Australian businessman politician and philanthropist
Usage examples of "parkin".
Wigtown Wanderers in the quarter-finals, and that was even with Wilmer Parkin in the pink of health.
Audra Griffiths, of the Holyhead Harpies, and Wilmer Parkin, of the Wigtown Wanderers, both tragically lost in the recent attack on Diagon Alley.
So it was Karen who answered the front door to Detective Sergeant Malone and Detective Constable Parkin, took their wet coats from them and escorted them into the big shabby sitting-room.
She ran upstairs to get her mother, and once she was sure that a protesting Margaret Meadows was safely installed in the bathroom in order to apply her obligatory layers of make-up, Karen ran downstairs again to make DS Malone and DC Parkin tea while they waited.
And once more, shortly after Malone and Parkin reported back, he decided to conduct another interview with Marshall himself.
He became aware of Malone and Parkin, who were also present yet again, fidgeting with discomfort.
Kitty, producing a paper bag and abstracting parkin, which she divided and the two of them shared.
Lord Drayton radiated a dangerous magic that made his steward, Parkin, want to flee for his life.
On the other hand, if Parkin could capture the beast, Drayton would be well pleased.
Meggie to shrink back in the stall as the steward, Parkin, impatiently strode down the center of the barn.
Today Parkin took her to a larger bedroom on the second floor and turned her over to a maid with instructions that Meggie be bathed.
The new dress Parkin had promised turned out to be a white nightgown trimmed with lace and far too large for her.
The armed men followed, joking among themselves until Parkin ordered them to be silent.
She gasped again, understanding why Parkin had said this would be a special kind of horse.
Worse, she had heard Parkin say the lord would return very soon to see his captive.