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The latency-associated nuclear antigen (LANA-1) or '''latent nuclear antigen ''' (LNA, LNA-1), is a Kaposi's sarcoma-associated herpesvirus ( KSHV) latent protein initially found by Moore and colleagues as a speckled nuclear antigen present in primary effusion lymphoma cells that reacts with antibodies from patients with KS. It is the most immunodominant KSHV protein identified by Western-blotting as 222–234 kDa double bands migrate slower than the predicted molecular weight. LANA has been suspected of playing a crucial role in modulating viral and cellular gene expression. It is commonly used as an antigen in blood tests to detect antibodies in persons that have been exposed to KSHV.

KSHV or Human herpesvirus 8 (HHV-8) has been identified as the etiological agent of Kaposi’s sarcoma (KS) and certain AIDS-associated lymphomas. As KSHV establishes latent infection in tumorous foci, it invariably expresses high levels of the viral LANA protein, which is necessary and sufficient to maintain the KSHV episome.

Encoded by ORF73, LANA-1 is one of few HHV-8 encoded proteins that is highly expressed in all latently infected tumour cells; specifically, it is a phosphoprotein with an acidic internal repeat domain flanked by a carboxy-terminal domain and an amino-terminal domain. LANA-1 acts as a transcriptional regulator, and it has been implicated directly in oncogenesis because of its ability to bind to the tumour-suppressing protein p53 and to the retinoblastoma protein pRb. This leads to the inactivation of p53-dependent promoters and induction of E2F-dependent genes.

Studies have also shown that LANA-1 can transactivate the promoter of the reverse transcriptase subunit of the human telomerase holoenzyme, thus overextending a critical step in cellular transformation. Paradoxically, LANA-1 has been shown to be involved in transcriptional repression and can, moreover, interact with the mSin3/HDAC1 co-repressor complex.

It has been also shown to interact with and inhibit the ATF4/CREB2 transcription factor that interacts with the basic transcription machinery and to bind with two human chromosome-associated cellular proteins, MeCP2 and DEK.

LANA-1 is associated with cellular chromatin and stays on the chromosomes during cell division. It maintains the viral genomes during cell division by tethering the viral episomes to the chromosomes. It binds directly to replication origin recognition complexes (ORCs) that are primarily associated with the terminal repeat (TR) region of the HHV-8 genome.

Lana (chimpanzee)

Lana (born on October 7, 1970) is a female chimpanzee, the first to be used in language research using lexigrams. She was born at the Yerkes National Primate Research Center of Emory University, and the project she was allocated to when 1 year old, the LANguage Analogue project led by Duane Rumbaugh, was named after her with the acronym LANA because the project team felt that her identity was well worth preserving (Rumbaugh, 1977, p. XXI).

Lana (given name)

Lana is a female given name and surname. Though its origin is disputed, it can be found most frequently in the English speaking countries, Russia, as well as many other European countries. "Lana" is short for Alana (in English) or Svetlana (in Russian), as well as a derivative of the Greek name Helen.

This name could come from the Gaelic ailin, meaning "little rock". The Irish Gaelic use of this name probably derives from the Gaelic phrase a , which was used to call a child.

Lana (album)

Lana is the first album released by Lana Jurčević, which contains 10 songs. Milana Vlaović wrote the songs.

Lana (wrestling)

Catherine Joy "C.J." Perry (born March 24, 1985) is an American actress, dancer, model, professional wrestling manager, professional wrestler, and singer currently signed to WWE under the ring nameLana, performing on the Raw brand as the manager of her real-life husband Rusev.

Usage examples of "lana".

And then Norvell had a bright idea and it took a lot more small bills to get the hackie to take them to Belly Rave and an hour to find Lana of the Wabbits.

Filing her thoughts for later consideration, Merissa made an effort to get Lana to drop the subject.

Lana Shuman collected comic books from the 1950s, as Nina had done for a time.

Lana may be going to the prom, but her boyfriend - not to mention his friends - never got detention for her.

Mohamed Amen, Antonia Artuso, Michelle Ballew, Ovidio Biaggi, David Bynoe, John Campbell, John Canoni, Gloria Cruz, Kevin Currenti, Miledys Diaz, Laysa Diaz, Mary Hamm, Ali Hassan, Roger Johnston, Moustapha Kone, Nancy Jacobs, Roseann Lentin, Vincent Mariano, Rich Marsillo, Tim Mercado, Glenn Krinsky, Mitchele Lewis, Barbara Melser, Sandy Olson, Rhonda Pomerantz, Jessica Porier, Lisa Rittel, Jose Rodriguez, Lana Rosenberg, Art Rosner, Jose Sanabria, Iris Sanchez-Hernandez, and Safokles Tsouros.

There is by now a vast library of described and filmed conversations, employing Ameslan and other gestural languages, with Washoe, Lucy, Lana and other chimpanzees studied by the Gardners and others.

With all the power of his being he pulled Lana up out of the water, grabbed her about the waist, and -- the raft dangerously atilt -- wrenched her sprawling onto the deck beside him.

In 1989, after divorcing his first wife, a Las Vegas real estate broker named Lana Padilla, he married Marife Torres, a nineteen-year-old Filapina from Cebu City.

Just as Washoe and Lucy can be said to speak, Lana can be said to write.

Lei si allontanò da me e, sollevato un morbido informe cappuccio dalle piega­ture di lana che le cadeva sulle spalle, se lo calò accurata­mente intorno al viso.

A subsequent investigation corroborated it to the extent of finding out the vessel in which his brother Ernest Lana had come over from South America.

Outside the railroad station, at the head of the cab rank, Lana began to cry.

It was made from the same composite materials as was Lanata, wood and ivory and hom.

Lana had, by January 1976, viewed The Developmental Anatomy of the Chimpanzee 245 times.

He had struck Durla as faint of heart during the questioning of the traitor, Rem Lanas, and positively disconcerted upon the imprisonment of Milifa.