n. (context enzyme genetics English) An enzyme in eukaryotic cells that adds a specific sequence of DNA to the telomeres of chromosomes after they divide; gives the chromosomes stability over time.
n. an enzyme in eukaryotic cells that can add telomeres to the ends of chromosomes after they divide
Telomerase, also called ' terminal transferase', is a ribonucleoprotein that adds a species-dependent telomere repeat sequence to the 3' end of telomeres. A telomere is a region of repetitive sequences at each end of a eukaryotic chromatid, which protects the end of the chromosome from deterioration or from fusion with neighbouring chromosomes. Telomerase, active in normal stem cells, is normally absent from, or at very low levels in, most somatic cells.
Telomerase is a reverse transcriptase enzyme that carries its own RNA molecule (e.g., with the sequence " C C C A A U C C C" in vertebrates) which is used as a template when it elongates telomeres.
Usage examples of "telomerase".
The idea of adding exogenous telomerase into cells is bound to be appealing.
Chow arrived four months after I had my first shot of telomerase inhibitor, two months after my tumors started shrinking and I began to think I might have some kind of chance.
The patient, assuming that the telomerase inhibitor was suitably applied, does not die.
If a patient were simply treated with telomerase inhibitor, death would soon follow.
Assuming that the delicate point is reached where the cancer is dead and the patient is not, a telomerase stimulator is administered.
Telomod therapy must juggle telomerase inhibition and stimulation, in a manner different for each patient.
You want an alternative technology that will allow you to continue to monitor your condition, and provide telomerase inhibitor or stimulator as needed.
But when they dripped the telomerase inhibitor into me through an IV, I knew the idea was to stop the cancer cells rebuilding the bits at the end of their chromosomes.
You just need to monitor this for yourself and learn when you need a telomerase inhibitor or stimulator.
So, you put the gene for telomerase inside a virus, have the virus infect cells, and then the cells will take up the gene and start making telomerase.
Because he had received injections of telomerase instead of gene therapy to keep producing it, his version of the aging disease had been less severe.
Braver introduces us to some of the scientific issues underlying the aging process, the role of telomerase and whether aging is in fact inevitable.
My guess is that tabulone activates the genes that produces telomerase, thereby maintaining a constant supply to keep the telomeres long and cells young.
As Elixir turns on the telomerase gene, instead of going twenty-eight, twenty-nine, thirty, death!
NCI she intended to study how tabulone deprived cancer cells of the telomerase enzyme, which was not the interest at Darby.