Wikipedia
Tumor protein p53, also known as p53, cellular tumor antigen p53 ( UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice). This homolog (originally thought to be, and often spoken of as, a single protein) is crucial in multicellular organisms, where it prevents cancer formation, thus, functions as a tumor suppressor. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation. Hence TP53 is classified as a tumor suppressor gene. ( Italics are used to denote the TP53 gene name and distinguish it from the protein it encodes.)
The name p53 was given in 1979 describing the apparent molecular mass; SDS-PAGE analysis indicates that it is a 53- kilodalton (kDa) protein. However, the actual mass of the full length p53 protein (p53α) based on the sum of masses of the amino acid residues is only 43.7 kDa. This difference is due to the high number of proline residues in the protein, which slow its migration on SDS-PAGE, thus making it appear heavier than it actually is. In addition to the full length protein, the human TP53 gene encodes at least 15 protein isoforms, ranging in size from 3.5 to 43.7 kDa. All these p53 proteins are called the p53 isoforms. The TP53 gene is the most frequently mutated gene (>50%) in human cancer, indicating that the TP53 gene plays a crucial role in preventing cancer formation. TP53 gene encodes proteins that bind to DNA and regulate gene expression to prevent mutations of the genome.
p53, was an experimental music group commissioned by English percussionist Chris Cutler to play at the 25th Frankfurt Jazz Festival in Germany in September 1994. Their performance was recorded and released by Recommended Records in 1996 on a live album entitled p53. The group reassembled in May 1997 to play at the Angelica International Festival of contemporary music in Bologna, Italy. In November 2006 an orchestral version with three soloists, Jon Rose, Zeena Parkins and Chris Cutler performed with the BBC Scottish Symphony Orchestra in Glasgow, Scotland, which was recorded and broadcast by the BBC in March 2007. This version was performed again at the Opera House in Milan in 2014 with the Orchestra de Teatro Communale, with soloists Daan Vandewalle and Thomas Dimuzio.
p53 was a musical improvisational project that centred on the music of two classical grand pianists, accompanied by percussion, homemade guitar, turntable scratching, and real-time sampling/processing of the pianists.
p53 is a 1996 live album by experimental music group p53. It was their debut album and was recorded at the 25th Frankfurt Jazz Festival in Germany on 1994. It was released in 1996 in the United Kingdom by Recommended Records.
p53 was a musical improvisational project that involved two classical grand pianists, a percussionist, a homemade guitarist and turntablist, and a real-time sampler/processor.
P53 may refer to:
- p53, a tumor suppressor protein
- p53 (band), an experimental music group
- p53 (album), a 1996 live album by experimental music group P53