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-ine is a suffix used in chemistry to denote two kinds of substance. The first is a chemically basic and alkaloidal substance. It was proposed by Joseph Louis Gay-Lussac in an editorial accompanying a paper by Friedrich Sertürner describing the isolation of the alkaloid "morphium", which was subsequently renamed to "morphine". Examples include quinine, morphine and guanidine. The second usage is to denote a hydrocarbon of the second degree of unsaturation. Examples include hexine and heptine. With simple hydrocarbons, this usage is identical to the IUPAC suffix -yne.

The suffix is usually pronounced either or depending on the word it appears in and the accent of the speaker. In a few words (for example, quinine and strychnine), the sound is normal in some accents. Gasoline ends with ; glycerine more often with than with .

The suffix -in is etymologically related and overlaps in usage with -ine. Many proteins and lipids have names ending with -in: for example, the enzymes pepsin and trypsin, the hormones insulin and gastrin, and the lipids stearin (stearine) and olein.