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Longman Dictionary of Contemporary English
irritation
noun
COLLOCATIONS FROM OTHER ENTRIES
skin irritation
▪ A lot of chemicals can cause skin irritation.
COLLOCATIONS FROM CORPUS
■ ADJECTIVE
mild
▪ Protocol 2 studied the phenomenon of adaptive cytoprotection in response to mild irritation of the duodenal mucosa in the three experimental groups.
▪ This protocol tested mucosal resistance to acid after mild irritation.
minor
▪ When an extended family is living together at close quarters, even minor irritations can grow out of all proportion.
▪ Socially adept children are often more forgiving, more likely to overlook minor irritations, and may also model appropriate behaviors.
▪ Which is a minor irritation for the itinerant tourist ... a daily nightmare for the local residents.
▪ Those are just minor stylistic irritations compared to Republican trickle-down economics.
▪ In happy marriages the partners don't make a big deal of minor irritations.
▪ But all of these are minor irritations in the world of the neighborhood swimming pool.
■ VERB
cause
▪ Though not as deadly as the sea wasp, this jellyfish can cause severe irritation if it stings a human.
▪ Formaldehyde in high concentrations can cause extreme irritation of the eyes, nose and throat if inhaled.
▪ He did pretty well what she wanted with their lives, which caused some occasional irritation.
▪ Initial attempts at moving together in a team often cause frustration and irritation.
▪ Some chemicals cause a direct irritation to the skin leading to dermatitis.
feel
▪ I felt the beginnings of irritation.
▪ But he felt irritation rising in him.
▪ Helen felt a wash of irritation.
▪ You are, as they say, stuck with it and have leisure to feel all its peculiar irritations and discomforts.
EXAMPLES FROM OTHER ENTRIES
▪ Attwood's metallic music was an irritation.
▪ Bailey expressed irritation with the inaccurate reports in the media.
▪ The heavy traffic is a constant source of irritation.
EXAMPLES FROM CORPUS
▪ But if the behaviour is repeated, and by the same fish, something is causing irritation and needs investigation.
▪ He turned towards her, but the blankets entangled his legs and he fought his eyes open in irritation.
▪ Protocol 2 studied the phenomenon of adaptive cytoprotection in response to mild irritation of the duodenal mucosa in the three experimental groups.
▪ So if you imagine that orders and irritation are going to intimidate me you're in for a big surprise!
▪ The ringing of the telephone came as a distinct irritation.
▪ There is a lesser one, which still remains an irritation.
The Collaborative International Dictionary
Irritation

Irritation \Ir`ri*ta"tion\, n. [L. irritatio: cf. F. irritation.]

  1. The act of irritating, or exciting, or the state of being irritated; excitement; stimulation, usually of an undue and uncomfortable kind; especially, excitement of anger or passion; provocation; annoyance; anger.

    The whole body of the arts and sciences composes one vast machinery for the irritation and development of the human intellect.
    --De Quincey.

  2. (Physiol.) The act of exciting, or the condition of being excited to action, by stimulation; -- as, the condition of an organ of sense, when its nerve is affected by some external body; esp., the act of exciting muscle fibers to contraction, by artificial stimulation; as, the irritation of a motor nerve by electricity; also, the condition of a muscle and nerve, under such stimulation.

  3. (Med.) A condition of morbid excitability or oversensitiveness of an organ or part of the body; a state in which the application of ordinary stimuli produces pain or excessive or vitiated action.

Douglas Harper's Etymology Dictionary
irritation

early 15c., in reference to sores and morbid swelling, from Middle French irritation or directly from Latin irritationem (nominative irritatio) "incitement, irritation," noun of action from past participle stem of irritare (see irritate).

Wiktionary
irritation

n. The act of irritating, or exciting, or the state of being irritated; excitement; stimulation, usually of an undue and uncomfortable kind; especially, excitement of anger or passion; provocation; annoyance; anger.

WordNet
irritation
  1. n. the psychological state of being irritated or annoyed [syn: annoyance, vexation, botheration]

  2. a sudden outburst of anger; "his temper sparked like damp firewood" [syn: pique, temper]

  3. (pathology) abnormal sensitivity to stimulation; "any food produced irritation of the stomach"

  4. the neural or electrical arousal of an organ or muscle or gland [syn: excitation, innervation]

  5. an uncomfortable feeling in some part of the body [syn: discomfort, soreness]

  6. unfriendly behavior that causes anger or resentment [syn: aggravation, provocation]

  7. the act of troubling or annoying someone [syn: annoyance, annoying, vexation]

Wikipedia
Irritation

Irritation, in biology and physiology, is a state of inflammation or painful reaction to allergy or cell-lining damage. A stimulus or agent which induces the state of irritation is an irritant. Irritants are typically thought of as chemical agents (for example phenol and capsaicin) but mechanical, thermal (heat), and radiative stimuli (for example ultraviolet light or ionising radiations) can also be irritants. Irritation also has non-clinical usages referring to bothersome physical or psychological pain or discomfort.

Irritation can also be induced by some allergic response due to exposure of some allergens for example contact dermatitis, irritation of mucousal membranes and pruritus. Mucosal membrane is most common site of irritation because it contains secretory glands that release mucous which attracts the allergens due to its sticky nature.

Chronic irritation is a medical term signifying that afflictive health conditions have been present for a while. There are many disorders that can cause chronic irritation, the majority involves the skin, vagina, eyes and lungs.

Usage examples of "irritation".

Not for the first time, Erik Hakkonsen stared in irritation at the heavy plate armor, as he stood sharpening the blade of his Algonquian war hatchet.

With the pea, therefore, the irritation from an attached object, and from geotropism when acting at right angles to the radicle, are nearly balanced forces.

She dusted her feet and boots with antifungal powder each morning, but every little irritation had to be treated immediately, before it became a major problem.

By then his irritation would have faded, and she would have restored Appleton Manor to its former glory.

But, outwardly at least, Beaumont had displayed little but gnawing irritation.

Once, in a fit of irritation with a Candiot who stammered out of sheer fright, the captain had ordered him to be hanged.

Eventually he collapsed onto the bed again, still fighting off paroxysms of chuckles while Erik stared at him in icy irritation.

Ard had turned in his chair to watch Coelin, and Jenna could see something akin to disgust, or maybe it was simply irritation, flicker across his face.

Ramelle sidestepped the martial show and Cora alternated between amusement and irritation.

He had won forty-five credits, and knew he had better quit before he caused irritation.

As the prostate gland becomes more irritated and inflamed from the natural progress of the disease, or from the irritation caused by the passage of instruments, or the employment of strong, harsh, stimulating diuretics, the urine becomes cloudy, and still later is found to have deposited during the night in the chamber utensil a quantity of thick, tenacious, and usually offensive mucus.

Even the physician can but suspect, till time develops more fully by hysterias, epilepsies, spinal irritations, and a train of symptoms unmistakable even if the finally extorted confession of the poor victim did not render the matter clear.

If the discharges contain much blood, a flannel cloth moistened with the spirits of turpentine should be laid over the lower part of the abdomen, and kept there until slight irritation is produced.

During childhood, particularly in scrofulous children, discharges from the vagina are not unfrequent, owing to worms or other intestinal irritation.

When she heard this movement Domini remembered her irritation against him at El-Akbara.