"___ up?"

• Start of a query to a practical tailor
• "_____ the use!"
• "___ the word?"
• "__ the big deal?"
• "___ My Line"
• "__ new with you?"
• "___ happening?"
• ''___ New Pussycat?''
• "--- new?"

Wiktionary Word definitions in Wiktionary
n. (plural of what English) Used as a stand-in to collectively pluralize arbitrary instances of things. Often used along with whys, hows, etc.