"___ Up, Doc?": 1972 film

• "___ in a name?"
• 4 Non Blondes "Scream from the top of my lungs, ___ going on?"
• "___ it to you?"
• "____ Happening!!"
• ' new?'
• "___ new?"
• "___ the problem?"
• "____ My Line?"

Wiktionary Word definitions in Wiktionary
n. (plural of what English) Used as a stand-in to collectively pluralize arbitrary instances of things. Often used along with whys, hows, etc.