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TOMSO, or 2- methoxy-4- methyl-5-methyl sulfinyl amphetamine, is a lesser-known psychedelic drug and a substituted amphetamine. TOMSO was first synthesized by Alexander Shulgin. In his book PiHKAL (Phenethylamines i Have Known And Loved), the dosage range is listed as 100–150 mg, and the duration listed as 10–16 hours. TOMSO is inactive on its own; it is activated with the consumption of alcohol. It produces intense time distortion and a threshold. Shulgin gives it a +++ on the Shulgin Rating Scale. Very little data exists about the pharmacological properties, metabolism, and toxicity of TOMSO.

TOMSO is synthesized from 5-TOM