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Sucrase-isomaltase (, oligo-1,6-glucosidase, limit dextrinase, isomaltase, exo-oligo-1,6-glucosidase, dextrin 6alpha-glucanohydrolase, alpha-limit dextrinase, dextrin 6-glucanohydrolase, oligosaccharide alpha-1,6-glucohydrolase) is a glucosidase enzyme located in on the brush border of the small intestine with systematic name oligosaccharide 6-alpha-glucohydrolase. Sucrase-isomaltase is a type II transmembrane glycoprotein located in the brush border of the small intestine. It has preferential expression in the apical membranes of enterocytes. The enzyme’s purpose is to digest dietary carbohydrates such as starch, glucose, and isomaltose. By further processing the broken-down products, energy in the form of ATP can be generated.