Find the word definition

Crossword clues for statin


n. (context pharmaceutical drug English) Any of a class of drugs (chiefly lactones or pyrroles) that lower the amount of cholesterol in the blood by inhibiting an enzyme involved in its biosynthesis.


n. a medicine that lowers blood cholesterol levels by inhibiting HMG-CoA reductase [syn: lipid-lowering medicine, lipid-lowering medication, statin drug]


Statins, also known as HMG-CoA reductase inhibitors, are a class of lipid-lowering medications that inhibit the enzyme HMG-CoA reductase which plays a central role in the production of cholesterol. High cholesterol levels have been associated with cardiovascular disease (CVD). Statins have been found to reduce cardiovascular disease and mortality in those who are at high risk. The evidence is strong that statins are effective for treating CVD in the early stages of a disease ( secondary prevention) and in those at elevated risk but without CVD ( primary prevention). Side effects of statins include muscle pain, increased risk of diabetes mellitus, and abnormalities in liver enzyme tests. Additionally, they have rare but severe adverse effects, particularly muscle damage.

As of 2010, a number of statins are on the market: atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin and simvastatin. Several combination preparations of a statin and another agent, such as ezetimibe/simvastatin, are also available. In 2005 sales were estimated at $18.7 billion in the United States. The best-selling statin is atorvastatin, which in 2003 became the best-selling pharmaceutical in history. The manufacturer Pfizer reported sales of US$12.4 billion in 2008. Due to patent expirations, several statins are now available as less expensive generics.