What is "simvastatin"

simvastatin \sim`va*stat"in\, n. a chemical substance ( C25H38O5) having inhibitory activity on the enzyme HMG-CoA reductase, and used in medicine to reduce cholesterol levels in blood.

Syn: synvinolin; MK-733; Zocor.

n. A hypolipidemic drug used to control hypercholesterolemia and to prevent cardiovascular disease.

n. an oral lipid-lowering medicine (trade name Zocor) administered to reduce blood cholesterol levels; recommended after heart attacks [syn: Zocor]

Simvastatin, marketed under the trade name Zocor among others, is a lipid-lowering medication. It is used along with exercise, diet, and weight loss to decrease elevated lipid (fat) levels. It is also used to decrease the risk of heart problems in those at high risk. It is taken by mouth.

Serious side effects may include muscle breakdown, liver problems, and increased blood sugar levels. Common side effects include constipation, headaches, and nausea. A lower dose may be needed in people with kidney problems. There is evidence of harm to unborn babies when taken during pregnancy and it should not be used by those who are breastfeeding. It is in the statin class of medications and works by decreasing the manufacture of cholesterol by the liver.

Simvastatin was developed by Merck and came into medical use in 1992. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. It is available as a generic medication. The wholesale cost in the developing world is 0.01 to 0.12 USD per day . In the United States it costs between 0.50 and 1.00 USD per day. Simvastatin is made from the fungus Aspergillus terreus.