Crossword clues for reelin
reelin
- Land, like a fish
- Land, in a boat
- Land, at sea?
- Land, at sea
- Land, as a pike
- Land, as a bass
- Land with a rod
- Land on the shore?
- Land on a lake?
- Land by the lake?
- Finish catching
- Catch, as a catfish
- Catch from the pier
- Catch from a pier, perhaps
- Catch from a pier
- Catch at the shore
- Catch at the pier
- Catch a fish
- Bring to shore
- Attract, as customers
- Land, as a fish
- Land, as a big one
- Catch, in a way
- Catch, as a catch-of-the-day
- Try to land
- Bring onto a boat, say
- Land on the sea?
- Wind a rod after a bite
- How to catch fish on line at sea?
- Catch, as a fish
- Prepare to land
- Land, angler-style
- Land on the sea
- Catch a catch-of-the-day
- Wind up with a fish?
- Try to catch, as a fish
- Retrieve with a fishing pole
- Pull out of the water
- Not leave at the end of the line
- Land, on the sea
Wiktionary
n. (context protein English) A protein that helps to regulate processes of neuronal migration and positioning in the developing brain.
Wikipedia
Reelin (RELN) is a large secreted extracellular matrix glycoprotein that helps regulate processes of neuronal migration and positioning in the developing brain by controlling cell–cell interactions. Besides this important role in early development, reelin continues to work in the adult brain. It modulates synaptic plasticity by enhancing the induction and maintenance of long-term potentiation. It also stimulates dendrite and dendritic spine development and regulates the continuing migration of neuroblasts generated in adult neurogenesis sites like subventricular and subgranular zones. It is found not only in the brain, but also in the spinal cord, blood, and other body organs and tissues.
Reelin has been suggested to be implicated in pathogenesis of several brain diseases. The expression of the protein has been found to be significantly lower in schizophrenia and psychotic bipolar disorder, but the cause of this observation remains uncertain as studies show that psychotropic medication itself affects reelin expression. Moreover, epigenetic hypotheses aimed at explaining the changed levels of reelin expression are controversial. Total lack of reelin causes a form of lissencephaly. Reelin may also play a role in Alzheimer's disease, temporal lobe epilepsy and autism.
Reelin's name comes from the abnormal reeling gait of reeler mice, which were later found to have a deficiency of this brain protein and were homozygous for mutation of the RELN gene. The primary phenotype associated with loss of reelin function is a failure of neuronal positioning throughout the developing central nervous system (CNS). The mice heterozygous for the reelin gene, while having little neuroanatomical defects, display the endophenotypic traits linked to psychotic disorders.