Wiktionary
alt. (context neuroscience English) A long-lasting (hours ''in vitro'', weeks to months ''in vivo'') increase, typically in amplitude, of the response of a postsynaptic neuron to a particular pattern of stimuli from a presynaptic neuron. n. (context neuroscience English) A long-lasting (hours ''in vitro'', weeks to months ''in vivo'') increase, typically in amplitude, of the response of a postsynaptic neuron to a particular pattern of stimuli from a presynaptic neuron.
Wikipedia
In neuroscience, long-term potentiation (LTP) is a persistent strengthening of synapses based on recent patterns of activity. These are patterns of synaptic activity that produce a long-lasting increase in signal transmission between two neurons. The opposite of LTP is long-term depression, which produces a long-lasting decrease in synaptic strength.
It is one of several phenomena underlying synaptic plasticity, the ability of chemical synapses to change their strength. As memories are thought to be encoded by modification of synaptic strength, LTP is widely considered one of the major cellular mechanisms that underlies learning and memory.
LTP was discovered in the rabbit hippocampus by Terje Lømo in 1966 and has remained a popular subject of research since. Many modern LTP studies seek to better understand its basic biology, while others aim to draw a causal link between LTP and behavioral learning. Still others try to develop methods, pharmacologic or otherwise, of enhancing LTP to improve learning and memory. LTP is also a subject of clinical research, for example, in the areas of Alzheimer's disease and addiction medicine.
Usage examples of "long-term potentiation".
But if one were to electrically stimulate the perforant pathway to the hippocampus, and get a great deal of adenosine triphosphate past the blood-brain barrier, for instance, thus stimulating the long-term potentiation that aided learning in the first place.
But if one were to electrically stimulate the perforant pathway to the hippocampus, and get a great deal of adenosine tri-phosphate past the blood-brain barrier, for instance, thus stimulating the long-term potentiation that aided learning in the first place.
Voronin, L L Long-term potentiation at neocortical level, in Matthies, H-J (ed.