Wiktionary
alt. (context idiomatic slang English) Something or someone that causes discomfort or frustration. n. (context idiomatic slang English) Something or someone that causes discomfort or frustration.
WordNet
n. something or someone that causes trouble; a source of unhappiness; "washing dishes was a nuisance before we got a dish washer"; "a bit of a bother"; "he's not a friend, he's an infliction" [syn: annoyance, bother, botheration, pain, infliction, pain in the neck]
Usage examples of "pain in the ass".
In Vulkahn slang, this is the English equivalent of pain in the ass.
I'm getting tired of being told I'm nuts or a pain in the ass or stupid.
He was putting all these dumb, show-offy ripples in the high notes, and a lot of other very tricky stuff that gives me a pain in the ass.