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The Collaborative International Dictionary
pachyderma

pachyderma \pachyderma\ (p[a^]k"[i^]*d[~e]r"m[.a]), n. (Med.) An abnormal thickening of the skin (usually unilateral on an extremity) caused by congenital enlargement of lymph vessel and lymph vessel obstruction.

Syn: pachydermatosis, pachydermia, nevoid elephantiasis.

Wiktionary
pachyderma

n. (context medicine English) Abnormal thickening of the skin.

WordNet
pachyderma

n. thickening of the skin (usually unilateral on an extremity) caused by congenital enlargement of lymph vessel and lymph vessel obstruction [syn: nevoid elephantiasis]

Wikipedia
Pachyderma

Pachyderma is the thickening of skin like that of a pachyderm. It occurs in the condition Pachydermoperiostosis; an X-linked genetic disorder.