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Answer for the clue "Thickening of the skin (usually unilateral on an extremity) caused by congenital enlargement of lymph vessel and lymph vessel obstruction ", 10 letters:
pachyderma

Word definitions for pachyderma in dictionaries

Wikipedia Word definitions in Wikipedia
Pachyderma is the thickening of skin like that of a pachyderm . It occurs in the condition Pachydermoperiostosis ; an X-linked genetic disorder .

The Collaborative International Dictionary Word definitions in The Collaborative International Dictionary
pachyderma \pachyderma\ (p[a^]k"[i^]*d[~e]r"m[.a]), n. (Med.) An abnormal thickening of the skin (usually unilateral on an extremity) caused by congenital enlargement of lymph vessel and lymph vessel obstruction. Syn: pachydermatosis, pachydermia, nevoid ...

WordNet Word definitions in WordNet
n. thickening of the skin (usually unilateral on an extremity) caused by congenital enlargement of lymph vessel and lymph vessel obstruction [syn: nevoid elephantiasis ]

Wiktionary Word definitions in Wiktionary
n. (context medicine English) Abnormal thickening of the skin.