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Noribogaine, or 12-hydroxyibogamine, is the principal psychoactive metabolite of the hallucinogenic drug ibogaine. It is thought to be involved in the antiaddictive effects of ibogaine-containing plant extracts, such as Tabernanthe iboga.

A recent study evaluated its effects on healthy volunteers at doses of 3–60 mg, finding no tolerability issues. A slow half-life of 28–49 hours was seen with large volume of distribution.