Wiktionary
vb. (context idiomatic colloquial English) To mess up; to confuse; to put into a state of disorder.
WordNet
v. make a mess of, destroy or ruin; "I botched the dinner and we had to eat out"; "the pianist screwed up the difficult passage in the second movement" [syn: botch, bumble, fumble, botch up, muff, blow, flub, screw up, ball up, spoil, muck up, bungle, fluff, bollix, bollix up, bollocks, bollocks up, bobble, mishandle, foul up, mess up, fuck up]
Usage examples of "louse up".
It would be a good show, all of it, even if they had to louse up the feature spectacle a little.
There was no reason to let you and Stubbs louse up a job I was working on.
If you louse up this match just once more, the next ball I serve will hit the tightest part of those fancy white shorts of yours -- right where the hip pocket would be if they had any -- and it'll raise a welt that will make you eat off of the mantel for three days.
If you louse up this match just once more, the next ball I serve will hit the tightest part of those fancy white shorts of yours—.
For me that's different from stealing files and trying to louse up or outsmart some congressional committee that's determined to knock us out of the box.
You know he ain't gonna do anything to louse up your little empire here.
I toyed with the idea of calling, but my resentment against all the known and unknown characters who were trying to louse up my vacation was too strong.