Wiktionary
alt. 1 (context vulgar English) An incompetent individual; one who errs frequently. 2 (context vulgar English) A severe mistake. n. 1 (context vulgar English) An incompetent individual; one who errs frequently. 2 (context vulgar English) A severe mistake. vb. 1 (context intransitive slang mildly vulgar English) to make a mistake, to go wrong 2 (context transitive vulgar English) to botch or make a mess of 3 (context transitive vulgar English) to injure or damage 4 (context used only in imperative vulgar English) short for ''shut the fuck up''.
WordNet
v. make a mess of, destroy or ruin; "I botched the dinner and we had to eat out"; "the pianist screwed up the difficult passage in the second movement" [syn: botch, bumble, fumble, botch up, muff, blow, flub, screw up, ball up, spoil, muck up, bungle, fluff, bollix, bollix up, bollocks, bollocks up, bobble, mishandle, louse up, foul up, mess up]
Usage examples of "fuck up".
You and Sid are going to fuck up everything before you're through.
I might lose a tooth or two, I suppose, or he could even break my arm or fuck up my eye!
Which worked, and because it worked the rest of the NFL bought Lombardi's whole style: Avoid Mistakes, Don't Fuck Up, Hang Tough and Take No Chances.