Lobaye is one of the 14 prefectures of the Central African Republic. Its capital is Mbaïki. The prefecture is located in the southern part of the country, bordering the Congo Republic and the Democratic Republic of the Congo. It shares borders with the prefectures of Mambéré-Kadéï to the northwest, Sangha-Mbaéré to the west, and Ombella-M'Poko to the northeast.
Besides Mbaïki, other important cities include Boda, in the north, and Mongoumba, by the Ubangi River.
Most of the inhabitants are coffea farmers. Most of the farmers are extremely poor; most children do not go to college, and many die due to lack of medical care. David Dacko, the first and third president of the Central African Republic from 1960-1965, and 1979-1981 is from Lobaye.