Wiktionary
n. (context carbohydrate English) The aldohexose ''(3S,4R,5R,6S)-6-methyloxane-2,3,4,5-tetrol'' present in several glycans and mucopolysaccharides
Wikipedia
Fucose is a hexose deoxy sugar with the chemical formula CHO. It is found on N-linked glycans on the mammalian, insect and plant cell surface, and is the fundamental sub-unit of the fucoidan polysaccharide. α(1→3) linked core fucose is a suspected carbohydrate antigen for IgE-mediated allergy.
Two structural features distinguish fucose from other six-carbon sugars present in mammals: the lack of a hydroxyl group on the carbon at the 6-position (C-6) (thereby making it a deoxy sugar) and the L -configuration. It is equivalent to 6-deoxy-L- galactose.
In the fucose-containing glycan structures, fucosylated glycans, fucose can exist as a terminal modification or serve as an attachment point for adding other sugars. In human N-linked glycans, fucose is most commonly linked α-1,6 to the reducing terminal β-N-acetylglucosamine. However, fucose at the non-reducing termini linked α-1,2 to galactose forms the H antigen, the substructure of the A and B blood group antigens.
Fucose is released from fucose-containing polymers by an enzyme called α- fucosidase.
L-Fucose is claimed to have application in cosmetics, pharmaceuticals, and dietary supplements. However, these claims are often not supported by peer-reviewed scientific studies.
Fucosylation of antibodies has been established to reduce binding to the Fc receptor (FcgammaRIIIA) of Natural Killer cells and thereby reduce antigen-dependent cellular cytotoxicity. Therefore therapeutic antibodies that are designed to recruit the immune system to cancers cells ave been manufactured in cell lines deficient in the enzyme for core fucosylation (FUT8) and thereby enhancing the in vivo cell killing.
Usage examples of "fucose".
I have injected contains a type of sugar, fucose, which the brain uses to synthesize some of the vital molecular components of its nerve cell membranes.
The experiment I was doing all those months ago when I began writing this book, which I described in Chapter 2, involved using the sugar fucose as a precursor for glycoprotein.
If we then take a biochemical marker, such as, say, increased fucose incorporation in the hours after training, we expect a difference between A and D, due to the training, and between C and F, as the delayed shock group has both tasted the bead and shows the memory.
If the biochemical change is the consequence simply of the experience of tasting the bead, then the level of fucose incorporation in E should be the same as that in D and F, and higher than in all the water groups A-C.
Bullock, S, Rose, S P R, and Zamani, R Characterisation and regional localisation of pre- and postsynaptic glycoproteins of the chick forebrain showing changed fucose incorporation following passive avoidance training.
Rose, S P R, and Jork, R Long-term memory formation in chick is blocked by 2-deoxygalactose, a fucose analogue.
Bullock, S, Rose, S P R, and Zamani, R Characterisation and regional localisation of pre- and postsynaptic glycoproteins of the chick forebrain showing changed fucose incorporation following passive avoidance training.
Bullock, S, Rose, S P R, and Zamani, R Characterisation and regional localisation of pre and postsynaptic glycoproteins of the chick forebrain showing changed fucose incorporation following passive avoidance training.