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FCM may refer to:

  • 1. FC Magdeburg
  • FC Midtjylland
  • Fuzzy cognitive map, a cognitive map which is processed based on fuzzy logic
  • Société Nouvelle des Forges et Chantiers de la Méditerranée, a French shipyard and historical tankproducer
  • Federation of Canadian Municipalities
  • Flash cache module, a variant of the dual-drive type of hybrid drives
  • Flow cytometry, a technique for counting microscopic particles suspended in fluid
  • Mexican Railway (reporting mark, short for Ferrocarril Mexicano)
  • Fuel containing material, a lava-like matter resulting from a reactor core meltdown
  • Franciscan Community of Mercy, a Franciscan religious order of the American National Catholic Church
  • Food contact materials
  • FCM (chemotherapy), a chemotherapy regimen consisting of fludarabine, cyclophosphamide and mitoxantrone
  • Futures Commission Merchant
FCM (chemotherapy)

FCM, or FMC in the context of chemotherapy is an acronym for a chemotherapy regimen that is often used in the treatment of indolent B cell non-Hodgkin's lymphomas.

In combination with Rituximab this regimen is called R-FCM or R-FMC, or FCM-R, FMC-R.

The [R]-FCM regimen contains

  1. (R)ituximab - anti-CD20 monoclonal antibody that can kill both normal and malignant CD20-bearing B cells;
  2. (F)ludarabine - an antimetabolite;
  3. (C)yclophosphamide - an alkylating antineoplastic agent from the oxazafosforine group;
  4. (M)itoxantrone - a synthetic antracycline analogue (antraquinone) that can intercalate DNA, thereby preventing cell division.

The FCM or R-FCM regimen is also sometimes used in some autoimmune diseases that are inherently sensitive to the use of rituximab, fludarabine, mitoxantrone, and cyclophosphamide alone in monotherapies (e.g., in severe multiple sclerosis flares).