afishoutofwater One who doesn't fit in Crocodile Dundee in Manhattan, e.g Topic of many comedies Premise of many sitcoms Premise of many comedies One no longer in his comfort zone Crocodile Dundee in Manhattan, say 4-, 7- or 10-Down? Misfit, in a phrase Misfit ... or what you get after the sequence described by the ends of 17-, 21-, 57- and 63-Across? One of the misfits One in unfamiliar surroundings, as 21 5? Misfit, proverbially