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Alternative clues for the word afishoutofwater

• Topic of many comedies
• 4-, 7- or 10-Down?
• Misfit, in a phrase
• Misfit, proverbially
• One in unfamiliar surroundings, as 21 5?
• One who doesn't fit in
• One no longer in his comfort zone
• Premise of many sitcoms
• Premise of many comedies