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3. 4-, 7- or 10-Down?

Alternative clues for the word afishoutofwater

• One in unfamiliar surroundings, as 21 5?
• Crocodile Dundee in Manhattan, say
• Crocodile Dundee in Manhattan, e.g
• One who doesn't fit in
• Misfit, proverbially
• Misfit, in a phrase
• Topic of many comedies
• Premise of many sitcoms
• Premise of many comedies
• One no longer in his comfort zone