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Answer for the clue "Informal assent ", 3 letters:
yup

Alternative clues for the word yup

Word definitions for yup in dictionaries

Wikipedia Word definitions in Wikipedia
YUP (Yhdistyneet Urbaanit Puoskarit, originally Y.U.P. Young Urban Perverts) is a Finnish rock -music group. The band arose amongst three students of the Savonlinna senior high of arts in 1987 and played some rather primitive, progressive hard-core punk ...

Douglas Harper's Etymology Dictionary Word definitions in Douglas Harper's Etymology Dictionary
1906, variant of yes .

Wiktionary Word definitions in Wiktionary
n. (context informal English) A yes; an affirmative answer. part. (context informal English) yes.

Usage examples of yup.

From my point of view, this spate of alarmism and yup pie penance rang false.

And if there were three synonyms to specify each amino acid, one might look at the code and say, yup, someone had carefully thought this out.