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3. Profound shift in outlook

Alternative clues for the word changeofheart

• Cardiologist's drastic remedy?
• EARTH
• Decision alteration
• Conversion
• Decision reversal ... or, literally, what can be found inside 17-, 22-, 49- and 58-Across
• Reversal in attitude
• Second thoughts
• Attitude reversal
• 2008 Jodi Picoult novel ... or a hint to the puzzle theme