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3. 2008 Jodi Picoult novel ... or a hint to the puzzle theme

Alternative clues for the word changeofheart

• Decision reversal ... or, literally, what can be found inside 17-, 22-, 49- and 58-Across
• Cardiologist's drastic remedy?
• Shift in compassion causing second thoughts
• Second thoughts
• EARTH
• Conversion
• Attitude reversal
• Profound shift in outlook
• Decision alteration