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Answer for the clue "Condition in which a person assumes the identity and permanently acts the part of the gender opposite to his or her biological sex ", 14 letters:
transsexualism

Word definitions for transsexualism in dictionaries

Wiktionary Word definitions in Wiktionary
n. transsexuality; the state of being transsexual.

Douglas Harper's Etymology Dictionary Word definitions in Douglas Harper's Etymology Dictionary
"intense desire to change one's sexual status, including the anatomical structure," 1953, coined by U.S. physician Harry Benjamin (1885-1986) from trans- + sexual . Transsexuality is recorded from 1941, but was used at first to mean "homosexuality" or "bisexuality." ...

WordNet Word definitions in WordNet
n. condition in which a person assumes the identity and permanently acts the part of the gender opposite to his or her biological sex

Usage examples of transsexualism.

The desire to live in the opposite gender is the essence of transgenderism, whereas the desire live as the opposite sex is the essence of transsexualism.

But the fact that we cannot fully explain the origins of transvestism of secondary transsexualism does not mean that a comprehensive theory is impossible.