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What is "transsexualism"

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transsexualism
Douglas Harper's Etymology Dictionary
transsexualism

"intense desire to change one's sexual status, including the anatomical structure," 1953, coined by U.S. physician Harry Benjamin (1885-1986) from trans- + sexual. Transsexuality is recorded from 1941, but was used at first to mean "homosexuality" or "bisexuality." In the current sense from 1955.

Wiktionary
transsexualism

n. transsexuality; the state of being transsexual.

WordNet
transsexualism

n. condition in which a person assumes the identity and permanently acts the part of the gender opposite to his or her biological sex

Usage examples of "transsexualism".

The desire to live in the opposite gender is the essence of transgenderism, whereas the desire live as the opposite sex is the essence of transsexualism.

But the fact that we cannot fully explain the origins of transvestism of secondary transsexualism does not mean that a comprehensive theory is impossible.