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Answer for the clue "The quality of being irreversible (once done it cannot be changed) ", 15 letters:
irreversibility

Word definitions for irreversibility in dictionaries

The Collaborative International Dictionary Word definitions in The Collaborative International Dictionary
Irreversibility \Ir`re*vers`i*bil"i*ty\, n. The state or quality of being irreversible; irreversibleness.

Wiktionary Word definitions in Wiktionary
n. The quality of being irreversible; the lack of an ability to be reversed.

WordNet Word definitions in WordNet
n. the quality of being irreversible (once done it cannot be changed) [ant: reversibility ]

Usage examples of irreversibility.

Death is a cluster concept and requires several criteria in a lump, but irreversibility is the only absolute one.