Wiktionary
n. (context medicine English) Any of a class of penicillin antibiotics in which an amino group has been replaced by a urea moiety
Wikipedia
The ureidopenicillins are a group of penicillins which are active against Pseudomonas aeruginosa.
There are three ureidopenicillins in clinical use:
- Azlocillin
- Piperacillin
- Mezlocillin
They are mostly ampicillin derivatives in which the amino acid side chain has been converted to a variety of cyclic ureas. It is speculated that the added side chain mimics a longer segment of the peptidoglycan chain, more than ampicillin, and thus would bind more easily to the penicillin-binding proteins. Ureidopenicillins are not resistant to beta-lactamases.
They are used parenterally, and are particularly indicated in infections caused by Gram-negative bacteria.