Crossword clues for thalidomide
Douglas Harper's Etymology Dictionary
1958, from "phthalimidoglutarimide," based on abbreviated form of naphthalene; a morning-sickness drug responsible for severe birth defects in Europe from 1956 to 1961, when it was withdrawn. It never was approved for use in America thanks to the efforts of Dr. Helen Brooke Taussig (1898-1986). Thalidomide baby is attested from 1962.
Wiktionary
n. (context pharmaceutical drug English) (RS)-2-(2,6-di-oxopiperidine-3-yl)-1H-isoindole-1,3(2H)di--one — carbon13hydrogen10nitrogen2oxygen4 — A drug that was sold during the late 1950s and 1960s as a sleeping aid, and to pregnant women as an antiemetic to combat morning sickness and other symptoms, but was withdrawn after being proven to cause severe birth defects, such as phocomelia; currently used to treat leprosy.
WordNet
n. a sedative and hypnotic drug; withdrawn from sale after discovered to cause severe birth defects because it inhibits angiogenesis
Wikipedia
Thalidomide sold under the brand names Immunoprin, among others, is an immunomodulatory drug and the prototype of the thalidomide class of drugs. Today, thalidomide is used mainly as a treatment of certain cancers ( multiple myeloma) and of a complication of leprosy.
Thalidomide was first marketed in 1957 in West Germany under the trade-name Contergan. The German drug company Chemie Grünenthal developed and sold the drug. Primarily prescribed as a sedative or hypnotic, thalidomide also claimed to cure " anxiety, insomnia, gastritis, and tension". Afterwards, it was used against nausea and to alleviate morning sickness in pregnant women. Thalidomide became an over-the-counter drug in West Germany on October 1, 1957. Shortly after the drug was sold in West Germany, between 5,000 and 7,000 infants were born with phocomelia (malformation of the limbs). Only 40% of these children survived. Throughout the world, about 10,000 cases were reported of infants with phocomelia due to thalidomide; only 50% of the 10,000 survived. Those subjected to thalidomide while in the womb experienced limb deficiencies in a way that the long limbs either were not developed or presented themselves as stumps. Other effects included deformed eyes and hearts, deformed alimentary and urinary tracts, blindness and deafness. The negative effects of thalidomide led to the development of more structured drug regulations and control over drug use and development.
Usage examples of "thalidomide".
She could literally feel her bones and organs shifting and changing as the recombinant invader transformed her very identity Visions of glowing mice and limbless thalidomide children infected her imagination, but when she looked down at her hands, afraid that all she would see were flippers, she discovered instead that her fingers were stretching before her eyes, growing longer and preternaturally more supple.
Marketing thalidomide in the Third World, for instance, long after the mutagenic tranquilizer had been discredited in the more advanced industrial nations, and investing in primitive cryogenics projects that sold a dubious promise of prolonged existence to the desperate, the fearful, and the terminally ill.
Mick Jagger and his new group, the Trashers, arrived on April 27, while the FBI was interviewing every whore in Las Vegas, and there quickly followed the Roofs, Moses and Monotheism, Steppenwolf, Civilization and Its Discontents, Poor Richard and His Rosicrucian Secrets, the Wrist Watch, the Nova Express, the Father of Waters, the Human Beings, the Washington Monument, the Thalidomide Babies, the Strangers in a Strange Land, Dr.
In 1998, thalidomide was approved to treat a rare disorder called erythema nodosum leprosum, and it may get approval for other diseases, like cancer, shortly.
Our technology has produced thalidomide, CFCs, Agent Orange, nerve gas, pollution of air and water, species extinctions, and industries so powerful they can ruin the climate of the planet.
She replied to Ursula, an ex-prostitute in Dortmund, and entered an online discussion about a potential Mexican source of thalidomide to relieve the ulcers in her mouth.
Only later was it discovered that in a small proportion of cases, thalidomide could cause a type of birth defect known as phocomelia, in which arms and legs are replaced by partially developed versions that resemble a seal's flippers.
He has made the bomb and the pill and the missile and the acid and the electric chair and the laser and the embalming fluid and the thalidomide baby in his own image.
A woman had killed her thalidomide baby and her sisters and doctor had all been involved.
The Manual now invites us to see ourselves as in utero and hype as thalidomide.