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What is "tamoxifen"

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tamoxifen
Longman Dictionary of Contemporary English
tamoxifen
noun
EXAMPLES FROM CORPUS
▪ The drug tamoxifen, first described in the late 1960s, has some value as a palliative in patients with oestrogen-dependent tumours.
▪ The greatest difference had been made by the hormonal drug tamoxifen, which was developed in Britain.
The Collaborative International Dictionary
Tamoxifen

Tamoxifen \Ta*mox"i*fen\ (t[a^]*m[o^]k"s[i^]*f[e^]n), n. a chemical compound ( C26H29NO) which is non-steroidal but physiogically active as an estrogen antagonist. It is used to treat postmenopausal breast cancer. Chemically it is 1-p-dimethylaminoethoxyphenyl-trans-1,2-diphenyl-but-1-ene. It can be obtained as a white crystalline powder.
--[MI11]

Syn: Kessar; Noltam; Nolvadex; Tamofen; Tamoxasta; Terimon; Xynoplex. [PJC]

Wiktionary
tamoxifen

n. A nonsteroidal estrogen antagonist used in the treatment of advanced breast cancer

WordNet
tamoxifen

n. an antagonist for estrogen that is used in the treatment of breast cancer [syn: estrogen antagonist]

Wikipedia
Tamoxifen

Tamoxifen (TMX), sold under the brand name Nolvadex among others, is a medication that is used to prevent breast cancer in women and treat breast cancer in women and men. It is also being studied for other types of cancer. It has been used for Albright syndrome. Tamoxifen is typically taken daily by mouth for five years for breast cancer.

Serious side effects include a small increased risk of uterine cancer, stroke, vision problems, and pulmonary embolism. Common side effects include irregular periods, weight loss, and hot flashes. It may cause harm to the baby if taken during pregnancy or breastfeeding. It is a selective estrogen-receptor modulator (SERM) that works both by decreasing factors that increase the growth of breast cells and increasing factors that decrease the growth of breast cells. It is of the triphenylethylene group.

Tamoxifen was discovered in 1967. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. Tamoxifen is available as a generic medication. The wholesale price in the developing world is about 0.07 to 0.23 USD per day. In the United States it costs about 2 USD a day.

Usage examples of "tamoxifen".

As each February day dawns colder and grayer than the last, Anna sinks into worries and depression, exhausted from neuropathy pain and hot flashes that remain months after stopping Taxol and tamoxifen.

A 1998 landmark study found that the use of tamoxifen in such women, who have no cancer but a family history of cancer or precancerous lesions, reduces the rate of expected breast cancers by 45 percent.