What is "talsaclidine"

n. A non-selective muscarinic acetylcholine receptor agonist.

Talsaclidine (WAL-2014) is a non- selective muscarinic acetylcholine receptor agonist which acts as a full agonist at the M subtype, and as a partial agonist at the M and M subtypes. It was under development for the treatment of Alzheimer's disease but showed only modest or poor efficacy in rhesus monkeys and humans, respectively, perhaps due to an array of dose-limiting side effects including increased heart rate and blood pressure, increased salivation, urinary frequency and burning upon urination, increased lacrimation and nasal secretion, abnormal accommodation, heartburn, upset stomach as well as cramps, nausea, vomiting and diarrhea, excessive sweating and palpitations.