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n. (context pharmacology English) A drug that is administered in an inactive form that is metabolised in the body into a biologically active compound.


A prodrug is a medication or compound that, after administration, is metabolized (i.e., converted within the body) into a pharmacologically active drug. Inactive prodrugs are pharmacologically inactive medications that are metabolized into an active form within the body. Instead of administering a drug directly, a prodrug might be used instead to improve how a medicine is absorbed, distributed, metabolized, and excreted ( ADME). Prodrugs are often designed to improve bioavailability when a drug itself is poorly absorbed from the gastrointestinal tract. A prodrug may be used to improve how selectively the drug interacts with cells or processes that are not its intended target. This reduces adverse or unintended effects of a drug, especially important in treatments like chemotherapy, which can have severe unintended and undesirable side effects.

Usage examples of "prodrug".

LIBERTY RALLY, which took place annually on historic Boston Common, had, over the course of its decade-long life, grown into the single largest prodrug event in the United States.