What is "polyamine oxidase"

n. (context enzyme English) Any enzyme that catalyzes the oxidation of a polyamine, but especially of acetylspermine to acetylspermidine and aminopropanal

In enzymology, a polyamine oxidase is an enzyme that catalyzes the chemical reaction

N-acetylspermine + O + HO $\rightleftharpoons$ N-acetylspermidine + 3-aminopropanal + HO

The 3 substrates of this enzyme are N1-acetylspermine, O, and HO, whereas its 3 products are N1-acetylspermidine, 3-aminopropanal, and HO.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with oxygen as acceptor. The systematic name of this enzyme class is N1-acetylspermidine:oxygen oxidoreductase (deaminating). This enzyme is also called 1-N-acetylspermidine:oxygen oxidoreductase (deaminating). It has 2 cofactors: FAD, and Iron. A similar enzyme in plants catalyzes non-acetylated polyamines.

Polyamine oxidase (propane-1,3-diamine-forming) (, MPAO, maize PAO) is an enzyme with systematic name spermidine:oxygen oxidoreductase (propane-1,3-diamine-forming). This enzyme catalyses the following chemical reaction

spermidine + O + HO $\rightleftharpoons$ propane-1,3-diamine + 4- aminobutanal + HO

The products of the reaction cannot be converted directly to other polyamines.