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pericyclic reaction

n. (context chemistry English) any reaction, typically involving organic compounds, in which a cyclic transition state is involved

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Pericyclic reaction

In organic chemistry, a pericyclic reaction is a type of organic reaction wherein the transition state of the molecule has a cyclic geometry, and the reaction progresses in a concerted fashion. Pericyclic reactions are usually rearrangement reactions. The major classes of pericyclic reactions are:

rowspan=2 |Name

colspan=2 |Bond changes

Sigma

Pi

Electrocyclic reaction

+ 1

Cycloaddition

+2

Sigmatropic reaction

0

Group transfer reaction

+ 1

Cheletropic reaction

+ 2

Dyotropic reaction

0

In general, these are considered to be equilibrium processes, although it is possible to push the reaction in one direction by designing a reaction by which the product is at a significantly lower energy level; this is due to a unimolecular interpretation of Le Chatelier's principle. Pericyclic reactions often have related stepwise radical processes associated with them. Some pericyclic reactions, such as the [2+2] cycloaddition, are 'controversial' because their mechanism is not definitively known to be concerted (or may depend on the reactive system). Pericyclic reactions also often have metal-catalyzed analogs, although usually these are also not technically pericyclic, since they proceed via metal-stabilized intermediates, and therefore are not concerted.

A large photoinduced hydrogen sigmatropic shift was utilized in a corrin synthesis performed by Albert Eschenmoser containing a 16π system.

Due to the principle of microscopic reversibility, there is a parallel set of "retro" pericyclic reactions, which perform the reverse reaction.