Wiktionary
n. (context biochemistry English) An actin-binding protein localized to the I-band of the sarcomeres in skeletal muscle.
Wikipedia
Nebulin is an actin-binding protein which is localized to the thin filament of the sarcomeres in skeletal muscle. It is a very large protein (600–900 kDa) and binds as many as 200 actin monomers. Because its length is proportional to thin filament length, it is believed that nebulin acts as a thin filament "ruler" and regulates thin filament length during sarcomere assembly. Other functions of nebulin, such as a role in cell signaling, remain uncertain.
Nebulin has also been shown to regulate actin-myosin interactions by inhibiting ATPase activity in a calcium- calmodulin sensitive manner.
Mutations in nebulin cause some cases of the autosomal recessive disorder nemaline myopathy.
A smaller member of the nebulin protein family, termed nebulette, is expressed in cardiac muscle.
Usage examples of "nebulin".
She had put away the sensible cotalene skirt and blazer she had worn most of the time on the starship and was now dressed in a dramatic formfitting bodysuit of metallic hunter-green nebulin with an ornate golden belt.
Paul Remillard was dressed in casual slacks of charcoal nebulin and a bulky red-and-white cardigan that Santa Claus might have envied.
She was flanked by Captain Ragnar Gathen, wearing his Twelfth Fleet uniform, and a crop-haired young woman in a burgundy nebulin business suit.