What is "nafoxidine"

n. A nonsteroidal antiestrogenic drug that has been investigated to treat advanced breast cancer.

Nafoxidine ( INN) (developmental code names U-11,000A, NSC-70735), or nafoxidine hydrochloride ( USAN), is a non-steroidal selective estrogen receptor modulator (SERM) or partial antiestrogen of the triphenylethylene group that was developed for the treatment of advanced breast cancer by Upjohn in the 1970s but was never marketed. It was developed at around the same time as tamoxifen and clomifene, which are also triphenylethylene derivatives. The drug was originally synthesized by the fertility control program at Upjohn as a postcoital contraceptive, but was subsequently repurposed for the treatment of breast cancer. It showed clinical effectiveness in breast cancer, but development was terminated due to the incidence of severe photophobia.