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The initials MDU may refer to:

  • Mains distribution unit, electrical device
  • Maharishi Dayanand University in Rohtak, Haryana, India
  • Manchester Debating Union
  • Medical Defence Union, medical defence organisation providing legal support should its members' clinical competence be questioned
  • Military Democratic Union (Unión Militar Democrática), clandestine Spanish organisation of military officers in the late- and post-Franco era.
  • MDU Resources (Montana-Dakota Utilities), American diversified energy company
  • Multi-dwelling unit, classification of housing
  • MDU, IATA airport code of Mendi Airport in Papua New Guinea