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MDE may refer to:

  • Methylenedioxyethylamphetamine (MDEA, MDE), a phenethylamine and amphetamine entactogen, psychedelic, and stimulant psychoactive drug
  • Master of Distance Education (MDE), a graduate degree offered by Athabasca University, Alberta, Canada
  • In Microsoft Access, .mde, the file extension for protected (compiled) databases
  • Mid-domain effect spatial/area hypotheses to explain Latitudinal gradients in species diversity
  • Model-driven engineering, the systematic use of models as primary engineering artifacts
  • The IATA code for José María Córdova International Airport, serving the Colombian city of Medellín.
  • Mitsubishi Design Europe, the design studio of Mitsubishi Motors Europe
  • Michigan Department of Education
  • Minnesota Department of Education
  • Mississippi Department of Education
  • Markit Document Exchange, platform used by financial market participants for distribution of account onboarding or KYC documents
  • Multi-disciplinary Engineering, an extrapolated version of systems engineering
  • Multivariate Density Estimation
  • Million Dollar Extreme, a comedy sketch group