What is "lipotoxicity"

n. (context pathology English) The result of the accumulation of lipids in tissue other than adipose tissue

Lipotoxicity is a metabolic syndrome that results from the accumulation of lipid intermediates in non- adipose tissue, leading to cellular dysfunction and death. The tissues normally affected include the kidneys, liver, heart and skeletal muscle. Lipotoxicity is believed to have a role in heart failure, obesity, and diabetes, and is estimated to affect approximately 25 % of the adult American population.