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lexitropsin

n. (context biochemistry English) Any of a class of semisynthetic DNA-binding ligands, several of which are antibiotics

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Lexitropsin

Lexitropsins are members of a family of semi-synthetic DNA-binding ligands. They are structural analogs of the natural antibiotics netropsin and distamycin. Antibiotics of this group can bind in the minor groove of DNA with different sequence-selectivity. Lexitropsins form a complexes with DNA with stoichiometry 1:1 and 2:1. Based on the 2:1 complexes were obtained ligands with high sequence-selectivity.