Wiktionary
n. (context biochemistry English) Any of a class of glycoproteins found in the basement membranes of most animal tissue
Wikipedia
Laminins are high- molecular weight (~400kDa) proteins of the extracellular matrix. They are a major component of the basal lamina (one of the layers of the basement membrane), a protein network foundation for most cells and organs. The laminins are an important and biologically active part of the basal lamina, influencing cell differentiation, migration, and adhesion.
Laminins are heterotrimeric proteins that contain an α-chain, a β-chain, and a γ-chain, found in five, four, and three genetic variants, respectively. The laminin molecules are named according to their chain composition. Thus, laminin-511 contains α5, β1, and γ1 chains. Fourteen other chain combinations have been identified in vivo. The trimeric proteins intersect to form a cross-like structure that can bind to other cell membrane and extracellular matrix molecules. The three shorter arms are particularly good at binding to other laminin molecules, which allows them to form sheets. The long arm is capable of binding to cells, which helps anchor organized tissue cells to the membrane.
The laminin family of glycoproteins are an integral part of the structural scaffolding in almost every tissue of an organism. They are secreted and incorporated into cell-associated extracellular matrices. Laminin is vital for the maintenance and survival of tissues. Defective laminins can cause muscles to form improperly, leading to a form of muscular dystrophy, lethal skin blistering disease ( junctional epidermolysis bullosa) and defects of the kidney filter ( nephrotic syndrome).
Usage examples of "laminin".
Without an admixture of laminin and nerve growth factor derived from Schwann cells, the graft might not have taken, and the composite Emir would have remained paralyzed from the neck down.
The Dewar flasks have the laminin and the nerve growth factor, both labeled.