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Kami-Amakusa

is a city located in Kumamoto Prefecture, Japan.

The modern city of Kami-Amakusa was established on March 31, 2004, from the merger of the towns of Himedo, Matsushima, Ōyano and Ryūgatake (all from Amakusa District).

As of 2005, the city has an estimated population of 35,314 and a population density of 280 persons per km². The total area is 126.06 km².