Wikipedia
Inocoterone ( INN), or as inocoterone acetate ( USAN) (developmental code names RU-882, RU-38882), also known as 17β-hydroxy-2,5-seco-A-dinorestr-9-en-5-one [acetate], is a non-steroidal antiandrogen that was developed in 1985 for topical administration but was never marketed. It was investigated for the treatment of acne but showed only modest (albeit statistically significant) efficacy in clinical trials. A reduction of 26% of lesions was observed in males treated with the drug after 16 weeks (~3.7 months). However, this is notably far less than that achieved with other agents such as benzoyl peroxide or antibiotics, which produce 50–75% reductions within 2 months. Similar poor results with the topical route have disappointingly been found for other antiandrogens such as cyproterone acetate and spironolactone.