What is "hemosiderosis"

hemosiderosis \hemosiderosis\ n. (Med.) The accumulation of abnormal amounts of hemosiderin in the tisssues. Several causes have been recognized.
--Stedman.

n. (context pathology English) An abnormal deposit of hemosiderin.

n. abnormal deposit of hemosiderin; often a symptom of thalassemia or hemochromatosis [syn: haemosiderosis]

Hemosiderosis ( AmE) or haemosiderosis ( BrE) is a form of iron overload disorder resulting in the accumulation of hemosiderin.

Types include:

• Transfusion hemosiderosis
• Idiopathic pulmonary hemosiderosis
• Transfusional diabetes

Hemosiderin deposition in the lungs is often seen after diffuse alveolar hemorrhage, which occurs in diseases such as Goodpasture's syndrome, granulomatosis with polyangiitis, and idiopathic pulmonary hemosiderosis. Mitral stenosis can also lead to pulmonary hemosiderosis. Hemosiderin collects throughout the body in hemochromatosis. Hemosiderin deposition in the liver is a common feature of hemochromatosis and is the cause of liver failure in the disease. Selective iron deposition in the beta cells of pancreatic islets leads to diabetes due to distribution of transferrin receptor on the beta cells of islets and in the skin leads to hyperpigmentation. Hemosiderin deposition in the brain is seen after bleeds from any source, including chronic subdural hemorrhage, cerebral arteriovenous malformations, cavernous hemangiomata. Hemosiderin collects in the skin and is slowly removed after bruising; hemosiderin may remain in some conditions such as stasis dermatitis. Hemosiderin in the kidneys has been associated with marked hemolysis and a rare blood disorder called paroxysmal nocturnal hemoglobinuria.

Hemosiderin may deposit in diseases associated with iron overload. These diseases are typically diseases in which chronic blood loss requires frequent blood transfusions, such as sickle cell anemia and thalassemia, though beta thalassemia minor has been associated with hemosiderin deposits in the liver in those with non-alcoholic fatty liver disease independent of any transfusions.