GCU may refer to:
- Global Currency Union, which presents a new way to denominate and settle cross-currency transaction at reduced risk of exchange rate deviation.
- Georgian Court University, Lakewood, New Jersey, United States
- The codonGCU for alanine
- General Contact Unit, a ship type of the Culture, fictional creation of author Iain M Banks
- Grand Canyon University, Phoenix, Arizona, United States
- Great Cities' Universities, an informal research-sharing association of urban universities in major metropolitan areas of the U.S.
- Greeting Card Universe, a website that sells paper greeting cards for any possible event and occasion.
- Glasgow Caledonian University, a university in Glasgow, Scotland